Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/57759
Título: T lymphocytes subsets and cytokine pattern induced by vaccination against bovine brucellosis employing S19 calfhood vaccination and adult RB51 revaccination
Palavras-chave: Calfhood vaccination
Revaccination of pregnant cattle
Cellular immunity
Brucellosis
Vacinação
Revacinação de gado prenhes
Editor: Elsevier
Citação: DORNELES, E. M. S. et al. T lymphocytes subsets and cytokine pattern induced by vaccination against bovine brucellosis employing S19 calfhood vaccination and adult RB51 revaccination. Vaccine, Kidlinton, v. 32, n. 46, p. 6034-6038, 21 Oct. 2014.
Resumo: The aims of this study were to address the protective immune response induced by S19 vaccination (n = 10) and RB51 revaccination, in pregnant (n = 9) and non-pregnant (n = 10) S19 calfhood-vaccinated cattle as follows: evaluate the in vitro CD4+ and CD8+ T-lymphocytes specific proliferation, and in vitro expression of IFN-γ by CD4+ and CD8+ T-cells and IL-4 by CD4+, CD8+ and CD21+ lymphocytes subset. Upon in vitro stimulation with γ-irradiated Brucella abortus 2308, blood mononuclear cells from S19 vaccinated and RB51 revaccinated cows exhibited significantly higher proliferation of CD4+ and CD8+ T-lymphocytes and CD4+IFN-γ+ T-cells compared to non-vaccinated animals. RB51 revaccination, regardless of the pregnancy status, did not enhance the proliferation of CD4+ or CD8+ T-cells nor IFN-γ or IL-4 production. Data from the present study suggest that cattle's cellular immune response induced after brucellosis vaccination and revaccination is due to CD4+ and CD8+ T-lymphocytes, being CD4+ T-cells the main source of IFN-γ.
URI: https://www.sciencedirect.com/science/article/pii/S0264410X14012183?via%3Dihub
http://repositorio.ufla.br/jspui/handle/1/57759
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