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Título: | T lymphocytes subsets and cytokine pattern induced by vaccination against bovine brucellosis employing S19 calfhood vaccination and adult RB51 revaccination |
Palavras-chave: | Calfhood vaccination Revaccination of pregnant cattle Cellular immunity Brucellosis Vacinação Revacinação de gado prenhes |
Editor: | Elsevier |
Citação: | DORNELES, E. M. S. et al. T lymphocytes subsets and cytokine pattern induced by vaccination against bovine brucellosis employing S19 calfhood vaccination and adult RB51 revaccination. Vaccine, Kidlinton, v. 32, n. 46, p. 6034-6038, 21 Oct. 2014. |
Resumo: | The aims of this study were to address the protective immune response induced by S19 vaccination (n = 10) and RB51 revaccination, in pregnant (n = 9) and non-pregnant (n = 10) S19 calfhood-vaccinated cattle as follows: evaluate the in vitro CD4+ and CD8+ T-lymphocytes specific proliferation, and in vitro expression of IFN-γ by CD4+ and CD8+ T-cells and IL-4 by CD4+, CD8+ and CD21+ lymphocytes subset. Upon in vitro stimulation with γ-irradiated Brucella abortus 2308, blood mononuclear cells from S19 vaccinated and RB51 revaccinated cows exhibited significantly higher proliferation of CD4+ and CD8+ T-lymphocytes and CD4+IFN-γ+ T-cells compared to non-vaccinated animals. RB51 revaccination, regardless of the pregnancy status, did not enhance the proliferation of CD4+ or CD8+ T-cells nor IFN-γ or IL-4 production. Data from the present study suggest that cattle's cellular immune response induced after brucellosis vaccination and revaccination is due to CD4+ and CD8+ T-lymphocytes, being CD4+ T-cells the main source of IFN-γ. |
URI: | https://www.sciencedirect.com/science/article/pii/S0264410X14012183?via%3Dihub http://repositorio.ufla.br/jspui/handle/1/57759 |
Aparece nas coleções: | DMV - Artigos publicados em periódicos |
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