Please use this identifier to cite or link to this item:
http://repositorio.ufla.br/jspui/handle/1/50852| Title: | New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus |
| Keywords: | (hydroxy)chloroquine Macrolide antibiotics Co-crystals SARS-CoV-2 Molecular modelling Hidroxicloroquina Antibióticos macrolídeos Cocristais Modelagem molecular |
| Issue Date: | 2022 |
| Publisher: | MDPI |
| Citation: | CASTRO, A. A. de et al. New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus. Covid, [S. l.], v. 2, n. 3, p. 230-243, 2022. DOI: 10.3390/covid2030018. |
| Abstract: | In this in silico study, different pharmaceutical co-crystals based on (hydroxy)chloroquine with macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) were analyzed for the first time. These findings present a new molecular perspective and therefore suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystal systems has less toxicity and is the most effective for inhibiting the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
| URI: | http://repositorio.ufla.br/jspui/handle/1/50852 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus.pdf | 3,85 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License
