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Campo DC | Valor | Idioma |
---|---|---|
dc.creator | Castro, Alexandre A. de | - |
dc.creator | Assis, Letícia C. | - |
dc.creator | Cunha, Elaine F. F. da | - |
dc.creator | Ramalho, Teodorico C. | - |
dc.creator | La Porta, Felipe A. | - |
dc.date.accessioned | 2022-08-05T18:31:37Z | - |
dc.date.available | 2022-08-05T18:31:37Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | CASTRO, A. A. de et al. New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus. Covid, [S. l.], v. 2, n. 3, p. 230-243, 2022. DOI: 10.3390/covid2030018. | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/50852 | - |
dc.description.abstract | In this in silico study, different pharmaceutical co-crystals based on (hydroxy)chloroquine with macrolide antibiotics (azithromycin, clarithromycin, or erythromycin A) were analyzed for the first time. These findings present a new molecular perspective and therefore suggest that the combination of (hydroxy)chloroquine/azithromycin, in the stoichiometric ratio of 1:1, as model co-crystal systems has less toxicity and is the most effective for inhibiting the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | MDPI | pt_BR |
dc.rights | Attribution 4.0 International | * |
dc.rights | acesso aberto | pt_BR |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Covid | pt_BR |
dc.subject | (hydroxy)chloroquine | pt_BR |
dc.subject | Macrolide antibiotics | pt_BR |
dc.subject | Co-crystals | pt_BR |
dc.subject | SARS-CoV-2 | pt_BR |
dc.subject | Molecular modelling | pt_BR |
dc.subject | Hidroxicloroquina | pt_BR |
dc.subject | Antibióticos macrolídeos | pt_BR |
dc.subject | Cocristais | pt_BR |
dc.subject | Modelagem molecular | pt_BR |
dc.title | New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | DQI - Artigos publicados em periódicos |
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Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_New In Silico insights into the application of (Hydroxy)Chloroquine with Macrolide Antibiotic Co-Crystals against the SARS-CoV-2 Virus.pdf | 3,85 MB | Adobe PDF | Visualizar/Abrir |
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