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Título : | Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques |
Autor: | Ishigaki, Hirohito Nakayama, Misako Kitagawa, Yoshinori Nguyen, Cong Thanh Hayashi, Kaori Shiohara, Masanori Gotoh, Bin Itoh, Yasushi |
Palavras-chave: | COVID-19 Coronavirus SARS-CoV-2 Neutralizing antibody Anticorpo neutralizante |
Publicador: | Elsevier |
Data da publicação: | Fev-2021 |
Referência: | ISHIGAKI, H. et al. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology, [S. l.], v. 554, p. 97-105, Feb. 2021. |
Abstract: | We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans. |
URI: | https://www.sciencedirect.com/science/article/pii/S0042682220302609#! http://repositorio.ufla.br/jspui/handle/1/45974 |
Idioma: | en_US |
Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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