Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/45974
metadata.artigo.dc.title: Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
metadata.artigo.dc.creator: Ishigaki, Hirohito
Nakayama, Misako
Kitagawa, Yoshinori
Nguyen, Cong Thanh
Hayashi, Kaori
Shiohara, Masanori
Gotoh, Bin
Itoh, Yasushi
metadata.artigo.dc.subject: COVID-19
Coronavirus
SARS-CoV-2
Neutralizing antibody
Anticorpo neutralizante
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: Feb-2021
metadata.artigo.dc.identifier.citation: ISHIGAKI, H. et al. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology, [S. l.], v. 554, p. 97-105, Feb. 2021.
metadata.artigo.dc.description.abstract: We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/pii/S0042682220302609#!
http://repositorio.ufla.br/jspui/handle/1/45974
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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