Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/45974
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dc.creatorIshigaki, Hirohito-
dc.creatorNakayama, Misako-
dc.creatorKitagawa, Yoshinori-
dc.creatorNguyen, Cong Thanh-
dc.creatorHayashi, Kaori-
dc.creatorShiohara, Masanori-
dc.creatorGotoh, Bin-
dc.creatorItoh, Yasushi-
dc.date.accessioned2021-01-05T16:10:58Z-
dc.date.available2021-01-05T16:10:58Z-
dc.date.issued2021-02-
dc.identifier.citationISHIGAKI, H. et al. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology, [S. l.], v. 554, p. 97-105, Feb. 2021.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0042682220302609#!pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/45974-
dc.description.abstractWe examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceVirologypt_BR
dc.subjectCOVID-19pt_BR
dc.subjectCoronaviruspt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectNeutralizing antibodypt_BR
dc.subjectAnticorpo neutralizantept_BR
dc.titleNeutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaquespt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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