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Campo DC | Valor | Idioma |
---|---|---|
dc.creator | Ishigaki, Hirohito | - |
dc.creator | Nakayama, Misako | - |
dc.creator | Kitagawa, Yoshinori | - |
dc.creator | Nguyen, Cong Thanh | - |
dc.creator | Hayashi, Kaori | - |
dc.creator | Shiohara, Masanori | - |
dc.creator | Gotoh, Bin | - |
dc.creator | Itoh, Yasushi | - |
dc.date.accessioned | 2021-01-05T16:10:58Z | - |
dc.date.available | 2021-01-05T16:10:58Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | ISHIGAKI, H. et al. Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. Virology, [S. l.], v. 554, p. 97-105, Feb. 2021. | pt_BR |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0042682220302609#! | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/45974 | - |
dc.description.abstract | We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Virology | pt_BR |
dc.subject | COVID-19 | pt_BR |
dc.subject | Coronavirus | pt_BR |
dc.subject | SARS-CoV-2 | pt_BR |
dc.subject | Neutralizing antibody | pt_BR |
dc.subject | Anticorpo neutralizante | pt_BR |
dc.title | Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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