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Title: | Alterações bioquímicas e hepáticas em ratos submetidos à uma dieta hiperlipídica/hiperenergética |
Other Titles: | Hepatic biochemical changes in rats submitted to a high-fat/high-energy diet |
Keywords: | Dieta hiperlipídica Doença hepática gordurosa não alcoólica Resistência à insulina Sobrepeso Diet High-fat Non-alcoholic fatty liver disease Insulin resistance Overweight |
Issue Date: | Nov-2012 |
Publisher: | Pontifícia Universidade Católica de Campinas |
Citation: | MOURA, L. P. de et al. Alterações bioquímicas e hepáticas em ratos submetidos à uma dieta hiperlipídica/hiperenergética. Revista de Nutrição, Campinas, v. 25, n. 6, p. 685-693, nov./dez. 2012. |
Abstract: | OBJECTIVE: The present study analyzed the biochemical and hepatic changes in adult rats fed a high-fat diet for two months. METHODS: Twenty Wistar rats 90 days old were divided into two groups, a control group consisting of normal weight rats fed a commercial rat chow and a diet group consisting of normal weight rats submitted to a semi-purified high-fat, high-energy diet. The animals in control group were kept on a commercial Purina® chow and those in diet group on a high-fat/high-energy diet containing 35% fat, of which 31% were from animal source (39% saturated fat) and 4% were from vegetable source (soybean oil). After 60 days of this experimental diet, the following were assessed: body weight, insulin sensitivity, blood glucose, serum insulin and free fatty acids, triglycerides, total lipids and hepatic lipogenic activity. RESULTS: Diet group presented higher body mass and insulin resistance. Blood glucose did not differ between the groups. A higher level of serum insulin and free fatty acids were found in diet group. Total lipids, triglycerides and lipogenic rate were also higher in group D. CONCLUSION: Therefore, the present findings demonstrate that two months of a high-fat/high-energy diet increases the body weight and hepatic free fatty acids and decreases insulin sensitivity of adult rats, typical signs of non-alcoholic fatty liver disease. |
URI: | http://repositorio.ufla.br/jspui/handle/1/45941 |
Appears in Collections: | DME - Artigos publicados em periódicos |
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File | Description | Size | Format | |
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ARTIGO_Alterações bioquímicas e hepáticas em ratos submetidos à uma dieta hiperlipídica-hiperenergética.pdf | 327,17 kB | Adobe PDF | View/Open |
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