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http://repositorio.ufla.br/jspui/handle/1/40990| Title: | Dichlorinated and Brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmannii |
| Keywords: | Halogenation Tryptophan Rugulovasine Dereplication Talaromyces |
| Issue Date: | Sep-2015 |
| Publisher: | MDPI Publishing |
| Citation: | MEDEIROS, L. S. de et al. Dichlorinated and Brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmannii. Molecules, [S.l.], v. 20, n. 9, p. 17627-17644, Sept. 2015. DOI: 10.3390/molecules200917627. |
| Abstract: | UHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with bromine sources. Studies from 1D/2D NMR and HRMS spectroscopy data allowed the structural elucidation of the dichlorinated compounds, while tandem MS/HRMS data analysis supported the rationalization of brominated congeners. Preliminary genetic studies revealed evidence that FADH2 dependent halogenase can be involved in the biosynthesis of the produced halocompounds. |
| URI: | http://repositorio.ufla.br/jspui/handle/1/40990 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_Dichlorinated and Brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmannii.pdf | 1,24 MB | Adobe PDF | View/Open |
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