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Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/40990
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Campo DCValorIdioma
dc.creatorMedeiros, Lívia Soman de-
dc.creatorSilva, José Vinícius da-
dc.creatorAbreu, Lucas Magalhães-
dc.creatorPfenning, Ludwig Heinrich-
dc.creatorSilva, Carolina Lúcia-
dc.creatorThomasi, Sérgio Secherrer-
dc.creatorVenâncio, Tiago-
dc.creatorPée, Karl-Heinz van-
dc.creatorNielsen, Kristian Fog-
dc.creatorRodrigues-Filho, Edson-
dc.date.accessioned2020-05-18T04:05:46Z-
dc.date.available2020-05-18T04:05:46Z-
dc.date.issued2015-09-
dc.identifier.citationMEDEIROS, L. S. de et al. Dichlorinated and Brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmannii. Molecules, [S.l.], v. 20, n. 9, p. 17627-17644, Sept. 2015. DOI: 10.3390/molecules200917627.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/40990-
dc.description.abstractUHPLC-DAD-HRMS based dereplication guided the detection of new halogenated alkaloids co-produced by Talaromyces wortmannii. From the fungal growth in large scale, the epimers 2,8-dichlororugulovasines A and B were purified and further identified by means of a HPLC-SPE/NMR hyphenated system. Brominated rugulovasines were also detected when the microbial incubation medium was supplemented with bromine sources. Studies from 1D/2D NMR and HRMS spectroscopy data allowed the structural elucidation of the dichlorinated compounds, while tandem MS/HRMS data analysis supported the rationalization of brominated congeners. Preliminary genetic studies revealed evidence that FADH2 dependent halogenase can be involved in the biosynthesis of the produced halocompounds.pt_BR
dc.languageen_USpt_BR
dc.publisherMDPI Publishingpt_BR
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceMoleculespt_BR
dc.subjectHalogenationpt_BR
dc.subjectTryptophanpt_BR
dc.subjectRugulovasinept_BR
dc.subjectDereplicationpt_BR
dc.subjectTalaromycespt_BR
dc.titleDichlorinated and Brominated rugulovasines, ergot alkaloids produced by Talaromyces wortmanniipt_BR
dc.typeArtigopt_BR
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