Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/57939
Title: Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study
Keywords: Coronavirus
COVID-19
Coronavirus infections
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Betacoronavirus
Intensive care units
Respiration
Noninvasive ventilation
Extracorporeal membrane oxygenation
Critical care outcomes
Mortality
Issue Date: 2021
Publisher: Instituto Israelita de Ensino e Pesquisa Albert Einstein
Citation: CORRÊA, T. D. et al. Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study. Einstein, São Paulo, 2021.
Abstract: Objective: To describe clinical characteristics, resource use, outcomes, and to identify predictors of in-hospital mortality of patients with COVID-19 admitted to the intensive care unit. Methods: Retrospective single-center cohort study conducted at a private hospital in São Paulo (SP), Brazil. All consecutive adult (≥18 years) patients admitted to the intensive care unit, between March 4, 2020 and February 28, 2021 were included in this study. Patients were categorized between survivors and non-survivors according to hospital discharge. Results: During the study period, 1,296 patients [median (interquartile range) age: 66 (53-77) years] with COVID-19 were admitted to the intensive care unit. Out of those, 170 (13.6%) died at hospital (non-survivors) and 1,078 (86.4%) were discharged (survivors). Compared to survivors, non-survivors were older [80 (70-88) versus 63 (50-74) years; p<0.001], had a higher Simplified Acute Physiology Score 3 [59 (54-66) versus 47 (42-53) points; p<0.001], and presented comorbidities more frequently. During the intensive care unit stay, 56.6% of patients received noninvasive ventilation, 32.9% received mechanical ventilation, 31.3% used high flow nasal cannula, 11.7% received renal replacement therapy, and 1.5% used extracorporeal membrane oxygenation. Independent predictors of in-hospital mortality included age, Sequential Organ Failure Assessment score, Charlson Comorbidity Index, need for mechanical ventilation, high flow nasal cannula, renal replacement therapy, and extracorporeal membrane oxygenation support. Conclusion: Patients with severe COVID-19 admitted to the intensive care unit exhibited a considerable morbidity and mortality, demanding substantial organ support, and prolonged intensive care unit and hospital stay.
URI: https://journal.einstein.br/article/clinical-characteristics-and-outcomes-of-covid-19-patients-admitted-to-the-intensive-care-unit-during-the-first-year-of-the-pandemic-in-brazil-a-single-center-retrospective-cohort-study/
http://repositorio.ufla.br/jspui/handle/1/57939
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