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Título: | Modelagem farmacocinética/farmacodinâmica do florfenicol para o tratamento da adenite equina por meio da simulação de Monte Carlo |
Título(s) alternativo(s): | Pharmacokinetic/pharmacodynamic modeling of florfenicol for the treatment of equine adenitis using Monte Carlo simulation |
Palavras-chave: | Antibioticoterapia Garrotilho Infecção bacteriana Medicina individualizada Antibiotic therapy Bacterial infection Individualized medicine |
Data do documento: | Jun-2021 |
Editor: | Universidade Federal Fluminense (UFF) |
Citação: | TAMEIRÃO, E. R. et al. Modelagem farmacocinética/farmacodinâmica do florfenicol para o tratamento da adenite equina por meio da simulação de Monte Carlo. Revista Brasileira de Ciência Veterinária, [S.l.], v. 28, n. 2, p. 75-80, abr./jun. 2021. DOI: 10.4322/rbcv.2021.014. |
Resumo: | The objective of this study was to evaluate the efficacy of florfenicol at the dose usually used in horses of 22 mg/kg by intravenous, intramuscular and oral routes for the treatment of equine adenitis caused by Streptococcus equi. subsp. equi, using Pharmacokinetic/ Pharmacodynamic (PK/PD) modeling and Monte Carlo simulation. A Monte Carlo simulation was performed from the PK parameters, then PK/PD modeling was performed to determine the antimicrobial efficacy rates for the treatment of this bacterial infection, according to the minimum inhibitory concentration (MIC) value, in a MIC range of 0.125 - 4 µg/mL. Intravenously, the probability of bacterial eradication was 100% for MICs up to 0.5 µg/mL, and the bacteriostatic effect was 99% and 80% for MICs of 2 and 4µg/mL, respectively. However, for the intramuscular and oral routes, the probability of reaching the bacteriologic eradication index was 100% for MICs of up to 0.5 µg/mL, however, it reaches values of 80% and 81%, respectively, for MICs of 1 µg/mL considering the bactericidal effect (p<0.01). Therefore, through this study the efficacy of florfenicol is evidenced up to the MIC of 0.5 µg/mL for the three routes of administration cited, however, for MICs higher than this value, it is essential to adjust the pharmacological dose, avoiding failures in therapy and possible microbial resistance. |
URI: | https://periodicos.uff.br/rbcv/article/view/48869 http://repositorio.ufla.br/jspui/handle/1/57299 |
Aparece nas coleções: | DMV - Artigos publicados em periódicos |
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