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Title: | Effect of resistance training combined with β-glucan ingestion on bone of ovariectomized mice |
Keywords: | β-glucan Mice - Osteoporosis Resistance training Ovariectomia Ratos - Osteoporose Treinamento de resistência Beta-glucana Estrogênio Estrogen |
Issue Date: | Jun-2022 |
Publisher: | Taylor & Francis Group |
Citation: | GALDINO-ALVES, D. A. et al. Effect of resistance training combined with β-glucan ingestion on bone of ovariectomized mice. Climacteric, London, 2022. DOI: https://doi.org/10.1080/13697137.2022.2077097. |
Abstract: | Objective: This study aimed to evaluate the effects of resistance training (RT) combined with prebiotic β-glucan (BG) ingestion (Saccharomyces cerevisiae) in ovariectomized (OVX) mice. Methods: Forty-eight mice were divided into six treatments: SHAM group and five OVX groups treated with saline (SAL), alendronate (ALE) (0.1 mg/kg), BG (62.5 mg/kg), RT (climbing a ladder with load) and the combination of BG + RT. All treatments were performed three times per week for 8 weeks starting 38 days after ovariectomy. Results: OVX effectiveness was confirmed by a reduction in uterus mass (p < 0.05). Femur weight was higher in the SHAM group, followed by the ALE and RT groups with intermediate values and the BG + RT, BG and SAL groups with the lowest values (p < 0.05). The bone mineral density (BMDDEXA) results were higher for the SHAM and RT groups compared to the other groups (p < 0.05). RT provided similar bone mass and resistance to fracture to ALE and SHAM. We found a similar number of osteocytes in the RT and SHAM groups, which was significantly higher than that found in animals receiving BG (p < 0.05). The BG + RT combination increased calcium bone concentration. Conclusion: RT promoted benefits on bone health in the OVX model, which were not complemented by the consumption of BG. |
URI: | https://doi.org/10.1080/13697137.2022.2077097 http://repositorio.ufla.br/jspui/handle/1/50535 |
Appears in Collections: | DME - Artigos publicados em periódicos |
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