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metadata.artigo.dc.title: | Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury |
metadata.artigo.dc.creator: | Lin, Yong Yuan, Jun Long, Quanxin Hu, Jieli Deng, Haijun Zhao, Zhenyu Chen, Juan Lu, Mengji Huang, Ailong |
metadata.artigo.dc.subject: | COVID-19 Coronavirus SARS-CoV-2 Abnormal liver function Liver injury Função hepática anormal Lesão hepática |
metadata.artigo.dc.publisher: | Elsevier |
metadata.artigo.dc.date.issued: | 2020 |
metadata.artigo.dc.identifier.citation: | LIN, Y. et al. Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury. Genes & Diseases, [S. l.], 2020. DOI: https://doi.org/10.1016/j.gendis.2020.11.005. |
metadata.artigo.dc.description.abstract: | To date, it remains unclear if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection exacerbates liver injury in patients with chronic hepatitis B virus (HBV) infection. In this study, we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019 (COVID-19) cases, including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19. We found that there were no significant differences for the discharge rate or duration of hospitalization between the two groups. However, inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests. The enhanced liver injury induced by SARS-CoV-2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type. Moreover, the inflammatory response, including abnormal lactate dehydrogenase, D-dimer and interleukin-6 production, may contribute to this injury following SARS-CoV-2 co-infection. Collectively, SARS-CoV-2 and HBV co-infection exacerbates liver function of the patients with COVID-19. |
metadata.artigo.dc.identifier.uri: | https://www.sciencedirect.com/science/article/pii/S2352304220301367#! http://repositorio.ufla.br/jspui/handle/1/45550 |
metadata.artigo.dc.language: | en_US |
Appears in Collections: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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