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http://repositorio.ufla.br/jspui/handle/1/42179| Título : | A thermostable mRNA vaccine against COVID-19 |
| Autor: | Zhang, Na-Na Li, Xiao-Feng Deng, Yong-Qiang Zhao, Hui Huang, Yi-Jiao Yang, Guan Huang, Wei-Jin Gao, Peng Zhou, Chao Zhang, Rong-Rong Guo, Yan Sun, Shi-Hui Fan, Hang Zu, Shu-Long Chen, Qi He, Qi Cao, Tian-Shu Huang, Xing-Yao Qiu, Hong-Ying Nie, Jian-Hui Jiang, Yuhang Yan, Hua-Yuan Ye, Qing Zhong, Xia Xue, Xia-Lin Zha, Zhen-Yu Zhou, Dongsheng Yang, Xiao Wang, You-Chun Ying, Bo Qin, Cheng-Feng |
| Palavras-chave: | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 mRNA vaccine Lipid nanoparticle Mouse adapted strain Non-human primate |
| Publicador: | Elsevier |
| Data da publicação: | 2020 |
| Referência: | ZHANG, N.-N. et al. A thermostable mRNA vaccine against COVID-19. Cell, [S.l.], 2020. No prelo. |
| Abstract: | There has been an urgent need of vaccines against coronavirus disease 2019 (COVID-19) due to the ongoing SARS-CoV-2 pandemic. Among all approaches, messenger RNA (mRNA) -based vaccine has emerged as a rapid and versatile platform to quickly respond to such a challenge. Here, we developed a lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (termed ARCoV). Intramuscular immunization of ARCoV mRNA-LNPs elicited robust neutralizing antibodies against SARS-CoV-2 as well as Th1-biased cellular response in mice and non-human primates. Two doses of ARCoV immunization in mice conferred complete protection against the challenge of a SARS-CoV-2 mouse adapted strain. Additionally, ARCoV was manufactured in liquid formulation and can be stored at room temperature for at least one week. This novel COVID-19 mRNA vaccine, ARCoV, is currently being evaluated in phase 1 clinical trials. |
| URI: | https://www.sciencedirect.com/science/article/pii/S0092867420309326 http://repositorio.ufla.br/jspui/handle/1/42179 |
| Idioma: | en_US |
| Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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