Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/41145
Title: Biological activities of the essential oil from the Moro orange peel (Citrus sinensis (L.) Osbeck)
Keywords: Natural products
Byproduct
Anticancer
Cytotoxicity
Antifungal activity
Produtos naturais
Subproduto
Anticâncer
Citotoxicidade
Atividade antifúngica
Issue Date: May-2020
Publisher: Wiley Online Library
Citation: MAGALHÃES, M. L. et al. Biological activities of the essential oil from the Moro orange peel (Citrus sinensis (L.) Osbeck). Flavour and Fragrance Journal, [S.I.], v. 35, n. 3, p. 294-301, May 2020.
Abstract: Citrus essential oils have become the focus of several researches, because they have broad biological activity, due to their chemical composition. However, there are few studies covering Moro orange essential oil. Thus, the aim of this study was to evaluate the effects of fresh Moro orange peel essential oil on antifungal, antioxidant, cytotoxic, and genotoxic activities in normal and tumor cells. The essential oil was extracted by hydrodistillation and characterized by GC/MS and GC/FID. Cytotoxicity was evaluated by MTS assay in normal cells (CCD‐1059Sk) and tumor cells (CCD‐1059Sk), and the genotoxicity was determined in normal cells by the comet assay. Antifungal activity was evaluated by the disk diffusion test against Aspergillus carbonarius and Aspergillus flavus filamentous fungi. The antioxidant activity was determined in DPPH, ABTS, and β‐carotene assay. The essential oil was mainly composed of monoterpenes such as limonene (95.12%), α‐pinene (0.35%), sabinene (0.54%), and myrcene (1.07%). The essential oil did not cause cell death after 48 hours of treatment in normal cells, but the cell viability of tumor cells decreased by 50% in the presence of the essential oil at a concentration of 272.6 μg/mL. Although no antioxidant effect was observed, the growth of all evaluated fungi was inhibited with a minimum inhibitory concentration (MIC) of 125 μL/mL. The essential oil from the Moro orange is promising for cancer treatment, and it can be used as a natural preservative in food systems.
URI: https://onlinelibrary.wiley.com/doi/full/10.1002/ffj.3561
http://repositorio.ufla.br/jspui/handle/1/41145
Appears in Collections:DZO - Artigos publicados em periódicos

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