Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/40905
Title: Experimental hydrophilic reactivator: bisoxime with three positive charges
Keywords: Reactivator
Oxime
Nerve agent
Docking study
Issue Date: 2019
Publisher: Springer
Citation: KUCA, K. et al. Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers, [S.l.], v. 73, p. 777-782, 2019.
Abstract: Within this study, experimental hydrophilic acetylcholinesterase (AChE) reactivator was evaluated in vitro against selected nerve agents (cyclosarin, tabun, sarin, VX agent). High hydrophilicity of the reactivator is caused by the presence of three positive charges in its molecule. Quaternary moiety involved in the connecting chain can influence linker’s interaction with the inner of the AChE. For the detailed description of reactivator-AChE interaction, docking studies were performed on theoretical models constructed from the chrystallographic structure of Mus musculus AChE (MmAChE).
URI: https://link.springer.com/article/10.1007/s11696-018-0612-6
http://repositorio.ufla.br/jspui/handle/1/40905
Appears in Collections:DQI - Artigos publicados em periódicos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.