Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/40905
Título: Experimental hydrophilic reactivator: bisoxime with three positive charges
Palavras-chave: Reactivator
Oxime
Nerve agent
Docking study
Data do documento: 2019
Editor: Springer
Citação: KUCA, K. et al. Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers, [S.l.], v. 73, p. 777-782, 2019.
Resumo: Within this study, experimental hydrophilic acetylcholinesterase (AChE) reactivator was evaluated in vitro against selected nerve agents (cyclosarin, tabun, sarin, VX agent). High hydrophilicity of the reactivator is caused by the presence of three positive charges in its molecule. Quaternary moiety involved in the connecting chain can influence linker’s interaction with the inner of the AChE. For the detailed description of reactivator-AChE interaction, docking studies were performed on theoretical models constructed from the chrystallographic structure of Mus musculus AChE (MmAChE).
URI: https://link.springer.com/article/10.1007/s11696-018-0612-6
http://repositorio.ufla.br/jspui/handle/1/40905
Aparece nas coleções:DQI - Artigos publicados em periódicos

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