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Título: | Prospection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasis |
Palavras-chave: | Lippia sidoides Medicinal chemistry Phospholipase inhibitors Proteases inhibitors Digestive enzymes inhibitors Antigenotoxic compounds Biological activity Química Medicinal Inibidores da fosfolipase Inibidores de proteases Inibidores das enzimas digestivas Atividades antigenotóxicas Atividade biológica |
Data do documento: | Mar-2019 |
Editor: | Wiley Online Library |
Citação: | BRAGA, M. A. et al. Prospection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasis. Chemistry & Biodiversity, Zurich, v. 16, n. 3, Mar. 2019. DOI: 10.1002/cbdv.201800558 |
Resumo: | The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α‐glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α‐amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use. |
URI: | https://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.201800558 http://repositorio.ufla.br/jspui/handle/1/40680 |
Aparece nas coleções: | DQI - Artigos publicados em periódicos |
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