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http://repositorio.ufla.br/jspui/handle/1/37626| Title: | Fish oil reduces the proliferation of cells cultured from human breast and colorectal tumours: an in vitro study |
| Keywords: | Cancer Fish oil Human Lipid hydroperoxides |
| Issue Date: | Dec-2015 |
| Publisher: | Elsevier |
| Citation: | BONATTO, S. J. R. et al. Fish oil reduces the proliferation of cells cultured from human breast and colorectal tumours: an in vitro study. Journal of Functional Foods, [S.l.], v. 19, part B, p. 941-948, Dec. 2015. |
| Abstract: | Diet plays a key role in the aetiology of cancer. Some studies have shown that diets rich in n-3 polyunsaturated fatty acids (n-3 PUFA) reduce tumour growth. This study aimed to investigate the effects of fish oil, rich in n-3 PUFA, in cell proliferation and death of cells from breast and colorectal tumours. In the presence of 1:5 (v/v) dilution of fish oil, 1.8-fold reduction in cell proliferation (p < 0.05) was observed. In addition, the presence of fish oil at a 1:5 proportion led to 1.6-fold increase in the rate of apoptosis, 6.7-fold increase in hydroperoxides, and 5-fold reduction in necrosis (p < 0.0001). |
| URI: | https://www.sciencedirect.com/science/article/pii/S1756464615004429#! http://repositorio.ufla.br/jspui/handle/1/37626 |
| Appears in Collections: | DNU - Artigos publicados em periódicos |
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