Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/33069
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dc.creatorRigonato-Oliveira, Nicole Cristine-
dc.creatorMacKenzie, BreAnne-
dc.creatorBachi, Andre Luis Lacerda-
dc.creatorOliveira Junior, Manoel Carneiro-
dc.creatorSantos-Dias, Alana-
dc.creatorBrandao-Rangel, Maysa Alves Rodrigues-
dc.creatorDelle, Humberto-
dc.creatorCosta-Guimaraes, Tamara-
dc.creatorDamaceno-Rodrigues, Nilsa Regina-
dc.creatorDulley, Larissa Hilário-
dc.creatorBenetti, Marcela Anhesini-
dc.creatorMalfitano, Christiane-
dc.creatorAngelis, Kátia de-
dc.creatorAlbertini, Regiane-
dc.creatorOliveira, Ana Paula Ligeiro-
dc.creatorAbbasi, Asghar-
dc.creatorNorthoff, Hinnak-
dc.creatorVieira, Rodolfo Paula-
dc.date.accessioned2019-02-27T10:19:02Z-
dc.date.available2019-02-27T10:19:02Z-
dc.date.issued2018-
dc.identifier.citationRIGONATO-OLIVEIRA, N. C. et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. Exercise Immunology, [S. l.], v. 24, p. 36-44, 2018.pt_BR
dc.identifier.urihttp://eir-isei.de/2018/eir-2018-036-article.pdfpt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/33069-
dc.description.abstractAcute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were preincubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1β, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1β, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1β, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production.pt_BR
dc.languageen_USpt_BR
dc.publisherInternational Society of Exercise and Immunologypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceExercise Immunologypt_BR
dc.subjectExercise immunologypt_BR
dc.subjectLung inflammationpt_BR
dc.subjectImmune responsept_BR
dc.subjectAcute lung injurypt_BR
dc.subjectCytokinespt_BR
dc.subjectImunologia do exercíciopt_BR
dc.subjectInflamação pulmonarpt_BR
dc.subjectResposta imunept_BR
dc.subjectLesão pulmonar agudapt_BR
dc.subjectCitocinaspt_BR
dc.titleAerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cellspt_BR
dc.typeArtigopt_BR
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