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Campo DC | Valor | Idioma |
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dc.creator | Rigonato-Oliveira, Nicole Cristine | - |
dc.creator | MacKenzie, BreAnne | - |
dc.creator | Bachi, Andre Luis Lacerda | - |
dc.creator | Oliveira Junior, Manoel Carneiro | - |
dc.creator | Santos-Dias, Alana | - |
dc.creator | Brandao-Rangel, Maysa Alves Rodrigues | - |
dc.creator | Delle, Humberto | - |
dc.creator | Costa-Guimaraes, Tamara | - |
dc.creator | Damaceno-Rodrigues, Nilsa Regina | - |
dc.creator | Dulley, Larissa Hilário | - |
dc.creator | Benetti, Marcela Anhesini | - |
dc.creator | Malfitano, Christiane | - |
dc.creator | Angelis, Kátia de | - |
dc.creator | Albertini, Regiane | - |
dc.creator | Oliveira, Ana Paula Ligeiro | - |
dc.creator | Abbasi, Asghar | - |
dc.creator | Northoff, Hinnak | - |
dc.creator | Vieira, Rodolfo Paula | - |
dc.date.accessioned | 2019-02-27T10:19:02Z | - |
dc.date.available | 2019-02-27T10:19:02Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | RIGONATO-OLIVEIRA, N. C. et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. Exercise Immunology, [S. l.], v. 24, p. 36-44, 2018. | pt_BR |
dc.identifier.uri | http://eir-isei.de/2018/eir-2018-036-article.pdf | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/33069 | - |
dc.description.abstract | Acute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were preincubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1β, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1β, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1β, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | International Society of Exercise and Immunology | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Exercise Immunology | pt_BR |
dc.subject | Exercise immunology | pt_BR |
dc.subject | Lung inflammation | pt_BR |
dc.subject | Immune response | pt_BR |
dc.subject | Acute lung injury | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | Imunologia do exercício | pt_BR |
dc.subject | Inflamação pulmonar | pt_BR |
dc.subject | Resposta imune | pt_BR |
dc.subject | Lesão pulmonar aguda | pt_BR |
dc.subject | Citocinas | pt_BR |
dc.title | Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | DME - Artigos publicados em periódicos |
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