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http://repositorio.ufla.br/jspui/handle/1/31936| Title: | New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger |
| Keywords: | Marine-derived fungi Aspergillus niger Furan derivative Cytotoxic activity Fungos derivados dos marinhos Derivado de furano Atividade citotóxica |
| Issue Date: | 2017 |
| Publisher: | Taylor & Francis |
| Citation: | UCHOA, P. K. S. et al. New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger. Natural Product Research, Abingdon, v. 31, n. 22, p. 2599-2603, 2017. |
| Abstract: | A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém’s offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL). |
| URI: | https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1283499?journalCode=gnpl20 http://repositorio.ufla.br/jspui/handle/1/31936 |
| Appears in Collections: | DFP - Artigos publicados em periódicos |
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