1. RI UFLA
  2. Escola de Ciências Agrárias de Lavras - ESAL
  3. Departamento de Agricultura - DAG
  4. DAG - Artigos publicados em periódicos
Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/56695
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Campo DCValorIdioma
dc.creatorRuas, Natalia Ritter-
dc.creatorPereira, Aline Carvalho-
dc.creatorPereira, Luciana Lopes Silva-
dc.creatorGermano, Carolina Mesquita-
dc.creatorCunha, Elaine Fontes Ferreira da-
dc.creatorCarvalho, Alexandre Alves de-
dc.creatorLameira, Osmar Alves-
dc.creatorPinto, José Eduardo Brasil Pereira-
dc.creatorBertolucci, Suzan Kelly Vilela-
dc.date.accessioned2023-04-24T15:39:30Z-
dc.date.available2023-04-24T15:39:30Z-
dc.date.issued2023-02-
dc.identifier.citationRUAS, N. R. et al. Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular docking. Chemistry & Biodiversity, [S.l.], v. 20, n. 2, Feb. 2023.pt_BR
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200760pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/56695-
dc.description.abstractThis studyaimedto quantifyverbascoside(VEB),performmoleculardockingstudiesof VEB with theα-glucosidase(GL) ofBacillusstearothermophilus,and evaluatethe inhibitionof the enzymebyL. dulcispreparations.The substrateconcentrationand presenceof reducedglutathionewere evaluatedfor their effecton thein vitroinhibitionof the GL enzyme.Assayswere also performedin the presenceand absenceofsimulatedgastricfluid. The antidiabeticfractions2 and 3 were the most inhibitedGL, but their activityweresignificantlydecreasedin the presenceof gastricfluid. Chromatographicanalysesconfirmedthe predominantpresenceof VEB in the samples.The sampleshad VEB concentrationsbetween49.9 and 243.5 mg/g.Simulationof the moleculardockingof VEB were consistentwith its GL-inhibitoryactivity.It can concludethat the crudeethanolextractand fractionsshow inhibitoryactivityagainstthe GL enzyme.pt_BR
dc.languageen_USpt_BR
dc.publisherWileypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceChemistry & Biodiversitypt_BR
dc.subjectMedicinal plantpt_BR
dc.subjectCapim docept_BR
dc.subjectHypoglycemic agentpt_BR
dc.subjectGlucosidase inhibitorspt_BR
dc.subjectPhenylethanoid glycosidept_BR
dc.titleInhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) preparations, quantification of verbascoside, and study of its molecular dockingpt_BR
dc.typeArtigopt_BR
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