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http://repositorio.ufla.br/jspui/handle/1/40754| metadata.artigo.dc.title: | Severe respiratory SARS-CoV2 infection: does ACE2 receptor matter? |
| metadata.artigo.dc.creator: | Perrotta, Fábio Matera, Maria Gabriella Cazzola, Mario Bianco, Andrea |
| metadata.artigo.dc.subject: | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) ACE-2 receptor ACE inhibitors Renin-angiotensin inhibitors |
| metadata.artigo.dc.publisher: | Elsevier |
| metadata.artigo.dc.date.issued: | Jul-2020 |
| metadata.artigo.dc.identifier.citation: | PERROTTA, F. et al. Severe respiratory SARS-CoV2 infection: does ACE2 receptor matter? Respiratory Medicine, [S.l.], v. 168, July 2020. |
| metadata.artigo.dc.description.abstract: | SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor. |
| metadata.artigo.dc.identifier.uri: | http://www.sciencedirect.com/science/article/pii/S0954611120301360 http://repositorio.ufla.br/jspui/handle/1/40754 |
| metadata.artigo.dc.language: | en_US |
| Appears in Collections: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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