Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/38956
Title: Alternativas para o tratamento da esquistossomose: caracterização físico-química do complexo de inclusão entre praziquantel e hidroxipropil-β-ciclodextrina
Other Titles: Alternatives for the Treatment of Schistosomiasis: Physico-Chemical Characterization of an Inclusion Complex Between Praziquantel and Hydroxypropyl-β-Cyclodextrin
Keywords: Ciclodextrina
Complexo de inclusão
Esquistossomose
Praziquantel
Cyclodextrin
Inclusion complex
Praziquantel
Schistosomiasis
Issue Date: 2010
Publisher: Colegio de Farmacéuticos de la provincia de Buenos Aires
Citation: CHAVES, I. S. et al. Alternativas para o tratamento da esquistossomose: caracterização físico-química do complexo de inclusão entre praziquantel e hidroxipropil-β-ciclodextrina. Latin American Journal of Pharmacy, Buenos Aires, v. 29, n. 7, p. 1067-1074, 2010.
Abstract: Praziquantel (PZQ) is the drug of choice commonly used for the treatment of shistosomiasis. However, it has low aqueous solubility, which could limit its bioavailability in the body. To circumvent these features, an inclusion complex with hydroxypropyl-beta-cyclodextrin (HP-β-CD) was prepared. Thus, the objective of this work was to prepare and characterize the PZQ/HP-β-CD inclusion complex. Morphological, spectroscopic, and calorimetric analysis showed the first signs of the guest/host interaction. The complexation kinetic analysis was used to determine the kinetic constant and, besides that, it was possible to establish the time consumed to reach equilibrium. Using the solubility isotherm, it was observed that the interaction with HP-β-CD increased 2.4 fold the aqueous solubility of plain PZQ. In vitro cytotoxicity tests, using fibroblast cells, evidenced no toxicity for these cells at the concentrations tested. These results demonstrated that there is a potential use of PZQ in formulations with HP-β-CD.
URI: http://www.latamjpharm.org/resumenes/29/7/LAJOP_29_7_1_2.pdf
http://repositorio.ufla.br/jspui/handle/1/38956
Appears in Collections:DQI - Artigos publicados em periódicos

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