Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/57613
Título: Simulação do efeito antinociceptivo de detomidina em cavalos
Título(s) alternativo(s): Detomidine anti-society effects simulation study in horses
Palavras-chave: Analises PK/PD
Analgésicos
Determinação de doses
PK / PD analyzes
Analgesics
Determination of doses
Data do documento: 2019
Editor: Centro Científico Conhecer
Citação: FONTANELA, M. A. C.; FERRANTE, M. Simulação do efeito antinociceptivo de detomidina em cavalos. Enciclopédia Biosfera, Goiânia, v. 16, n. 29, p. 827-834, 2019.
Resumo: This study aimed to simulate the antinociceptive effect of detomidine IV and IM in horses at a dose of 80 ug / kg. The pharmacokinetic / pharmacodynamic analysis was performed using the equation. Pharmacokinetic and pharmacodynamic data were those corresponding to the study at doses of 30æg / kg. The antinociceptive effect was considered from the nociceptive threshold changes. Finally, the antinociceptive effect was determined from the high doses of detomidine (80 ug / kg) from the plasma concentrations by means of a simulation. The simulated antinociceptive effect from plasma concentrations corresponding to doses of 80 ug / kg was 90%, 80% and 40% up to 120, 180 and 240 minutes for the IM route and was 90%, 80% and 60% up to 120, 180 and 240 minutes for the IV route, respectively. Elevated doses of detomidine determine superior and more gilding effects at doses of 30æg / kg by respective routes of administration. However, in vivo studies complete at these high doses are required to verify adverse effects.
URI: http://repositorio.ufla.br/jspui/handle/1/57613
Aparece nas coleções:DMV - Artigos publicados em periódicos

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