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Título: | The polymorphisms of genes associated with the profile of fatty acids of sheep |
Título(s) alternativo(s): | Os polimorfismos de genes associados ao perfil de ácidos graxos de ovinos |
Palavras-chave: | Diacylglycerol acyltransferase Fatty acid synthase Stearoyl-CoA desaturase Diacilglicerol aciltransferase Ácido graxo sintase Estearoil-CoA dessaturase |
Data do documento: | 2019 |
Editor: | Universidade Federal de Minas Gerais, Escola de Veterinária |
Citação: | ESTEVES, C. et al. The polymorphisms of genes associated with the profile of fatty acids of sheep. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Belo Horizonte, v. 71, n. 1, Jan./Feb. 2019. |
Resumo: | The present study aimed to evaluate the occurrence of polymorphisms in Diacylglycerol acyltransferase (DGTA-1 and 2), Fatty acid synthase (FASN), Stearoyl-CoA desaturase (SCD) genes and the Thioesterase domain of FASN (TE-FASN) gene that may be related to the lipid profile. In the experiment, a total of 84 sheep from different genetic groups were used. For the evaluation of the polymorphism of the genes, PCR-Single Strand Conformation Polymorphism (SSCP) technique and subsequent sequencing were used. In DGAT-2 gene, four genotypes were identified with the presence of 6 polymorphisms, with two (c.229T> C; c.255T> C) that resulted into the exchange of phenylalanine by leucine. In FASN gene, two genotypes were identified. In TE-FASN gene, three genotypes and 17 polymorphisms were identified. DGAT-1 and SCD genes did not reveal the occurrence of polymorphism. There was difference in relation to C14: 0, C18: 0 fatty acids and Δ9-desaturase C18 for DGAT-2 gene and of C18: 2ω6t for TE-FASN. There were differences among the genetic groups for C10: 0, C12: 0, C17: 0, C18: 2ω6t, C18: 3ω3, C20: 2, total of ω3, ω3/ω6 and atherogenicity index. There is occurrence of polymorphism of DGAT-2 and TE-FASN genes and these should be further studied in sheep since they revealed influence of the genotypes on the fatty acid profile. |
URI: | http://repositorio.ufla.br/jspui/handle/1/57389 |
Aparece nas coleções: | DMV - Artigos publicados em periódicos |
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