Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/57336
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dc.creatorCarvalho, Lucas Bragança de-
dc.creatorBurusco, Kepa Koldo-
dc.creatorJaime, Carlos-
dc.creatorVenâncio, Tiago-
dc.creatorCarvalho, Aline Ferreira Souza de-
dc.creatorMurgas, Luis David Solis-
dc.creatorPinto, Luciana de Matos Alves-
dc.date.accessioned2018-11-23T18:03:47Z-
dc.date.accessioned2023-06-27T18:38:19Z-
dc.date.available2018-11-23T18:03:47Z-
dc.date.available2023-06-27T18:38:19Z-
dc.date.issued2018-01-01-
dc.identifier.citationCARVALHO, L. B. de et al. Complexes between methyltestosterone and β-cyclodextrin for application in aquaculture production. Carbohydrate Polymers, Barking, v. 179, p. 386-393, 1 Jan. 2018.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0144861717310494#!pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/57336-
dc.description.abstractThe inclusion complexes between 17-α-methyltestosterone (MT) and β-cyclodextrin (bCD) were prepared and characterized in dissolution and solid phase. The complex promoted a sixfold increment in solubility of the hormone. It has a limited solubility and stoichiometry of 2:1 (bCD:MT) determined by DSC, NMR and solubility experiments, the association constant Ka = 2846 L mol−1 and complex fraction of 76% (assessed by DOSY-NMR, in (1:3) DMSO/D2O). The association constant obtained in water by the solubility isotherms is 7540 L mol−1. 2D-ROESY experiments indicate the intermolecular orientation (complete inclusion of the hormone in the cavity). Simulations by molecular dynamics agreed with the formation of the inclusion complex 2:1. Release tests showed the slower release for the complexes, with 50% for lyophilization and 56% for malaxation. These results clearly demonstrate the complexation of MT in bCD, which formulations are promising for further applications involving this steroid in aquaculture, both for sexual reversal and in technologies of hormone in water sequestration.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceCarbohydrate Polymerspt_BR
dc.subjectCyclodextrinpt_BR
dc.subjectInclusion complexpt_BR
dc.subjectMethyltestosteronept_BR
dc.subjectHormonal sex reversalpt_BR
dc.subjectAquaculturept_BR
dc.subjectCiclodextrinapt_BR
dc.subjectComplexo de Inclusãopt_BR
dc.subjectMetiltestosteronapt_BR
dc.subjectReversão sexual hormonalpt_BR
dc.subjectAquiculturapt_BR
dc.titleComplexes between methyltestosterone and β-cyclodextrin for application in aquaculture productionpt_BR
dc.typeArtigopt_BR
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