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http://repositorio.ufla.br/jspui/handle/1/57100
Título: | Expression of EGFR family and p53 in a patient with synchronous primary endometrial adenocarcinoma and clear cell renal carcinoma: a case report |
Palavras-chave: | Endometrial carcinoma Renal clear cell carcinoma Carcinoma endometrial Carcinoma renal de células claras |
Data do documento: | 2019 |
Citação: | MARTINS, P. F. da S. et al. Expression of EGFR family and p53 in a patient with synchronous primary endometrial adenocarcinoma and clear cell renal carcinoma: a case report. Brazilian Journal of Oncology, [S.l.], v. 15, 2019. |
Resumo: | We present a case of a 69 year-old, non-obese, post-menopausal woman diagnosed with synchronous endometrial adenocarcinoma and renal cell carcinoma. Immunolocalization and expression of the EGFR, HER-2, HER-3, HER-4 and p53 proteins by immunohistochemistry (IHC) was performed to investigate synchronous expression of these proteins. The endometrial adenocarcinoma was a well-differentiated tumor, with discernable glandular structure with moderate mitotic index. IHC revealed weak HER-2, HER-3 and HER-4 staining of cell membranes in well-differentiated areas, and intense HER-2 and p53 staining in papillary areas. The renal cell carcinoma showed clear cell type, solid tumor, Fuhrman nuclear grade 2, presence of necrosis and hemorrhage. IHC revealed intense HER-2 and HER-4 staining of cell membranes, weak EGFR staining, and negative expression for HER3 and p53 protein. In summary, overexpression of HER-2 and HER-4 may correlate with histological grade of the tumor and patient prognosis. |
URI: | http://www.brazilianjournalofoncology.com.br/details/65/en-US/expression-of-egfr-family-and-p53-in-a-patient-with-synchronous-primar http://repositorio.ufla.br/jspui/handle/1/57100 |
Aparece nas coleções: | DMV - Artigos publicados em periódicos |
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