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dc.creatorPereira, Jéssica Petrine Castro-
dc.creatorOliveira, Erika Aparecida-
dc.creatorPereira, Fernanda Aparecida Castro-
dc.creatorSeixas, Josilene Nascimento-
dc.creatorGuimaraes, Camila Souza de Oliveira-
dc.creatorBorges, Bruno Del Bianco-
dc.date.accessioned2022-09-27T17:42:27Z-
dc.date.available2022-09-27T17:42:27Z-
dc.date.issued2022-08-
dc.identifier.citationPEREIRA, J. P. C. et al. Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats. Nutrients, Basel, v. 14, n. 15, 3238, 2022. DOI: 10.3390/nu14153238.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/55212-
dc.description.abstractLow endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action.pt_BR
dc.languageenpt_BR
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)pt_BR
dc.rightsAttribution 4.0 International*
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceNutrientspt_BR
dc.subjectPhytoestrogenspt_BR
dc.subjectAntioxidantspt_BR
dc.subjectEstrogenpt_BR
dc.subjectCompound phenolicspt_BR
dc.subjectMetabolismpt_BR
dc.subjectBody weightpt_BR
dc.subjectFitoestrógenospt_BR
dc.subjectAntioxidantespt_BR
dc.subjectEstrogêniopt_BR
dc.subjectCompostos fenólicospt_BR
dc.subjectMetabolismopt_BR
dc.subjectPeso corporalpt_BR
dc.subjectRatas - Ovariectomiapt_BR
dc.titleBeneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar ratspt_BR
dc.typeArtigopt_BR
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