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dc.creatorCosta, Thaís C.-
dc.creatorMendes, Tiago A. O.-
dc.creatorFontes, Marta M. S.-
dc.creatorLopes, Mariana M.-
dc.creatorDu, Min-
dc.creatorSerão, Nick V. L.-
dc.creatorSanglard, Leticia M. P.-
dc.creatorBertolini, Francesca-
dc.creatorRothschild, Max F.-
dc.creatorSilva, Fabyano F.-
dc.creatorGionbelli, Mateus P.-
dc.creatorDuarte, M. S.-
dc.date.accessioned2022-06-10T22:30:20Z-
dc.date.available2022-06-10T22:30:20Z-
dc.date.issued2021-06-
dc.identifier.citationCOSTA, T. C. et al. Transcriptome changes in newborn goats’ skeletal muscle as a result of maternal feed restriction at different stages of gestation. Livestock Science, [S. I.], v. 248, 104503, Jun. 2021. DOI: https://doi.org/10.1016/j.livsci.2021.104503.pt_BR
dc.identifier.urihttps://doi.org/10.1016/j.livsci.2021.104503pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/50198-
dc.description.abstractWe investigated how feed restriction at 50% of maintenance requirements during different stages of gestation affects the transcriptome of newborn goats’ skeletal muscle. Fourteen pregnant dams were randomly assigned into one of the following dietary treatments: animals fed at 50% of maintenance requirement from 8–84 d of gestation and then fed at 100% of maintenance requirement from day 85 of gestation to parturition (RM, n = 6), and animals fed at 100% of maintenance requirement from 8–84 d of gestation and then fed at 50% of maintenance requirement from day 85 of gestation to parturition (MR, n = 8). At birth, samples of offspring's Longissimus muscle were collected for total RNA extraction and sequencing. Our data showed 66 differentially expressed (DE) genes (FDR < 0.05). A total of 6 genes were upregulated and 60 downregulated (FDR < 0.05) in the skeletal muscle of the newborns resulting from treatment RM compared with MR. Our results suggest that the DE genes upregulated in newborn goats’ skeletal muscle from the RM group compared to MR, included genes related to satellite cells, and genes that indicates impaired insulin sensitivity and changes in the composition of intramuscular fat. The DE genes upregulated in newborn goats’ skeletal muscle from the MR group compared to RM, are also related to impaired insulin sensitivity, as well as a predominantly oxidative metabolism and cellular oxidative stress. However, protective mechanisms against insulin sensitivity and oxidative stress may have been augmented in the skeletal muscle of offspring from MR treatment compared to RM, in order to maintain cellular homeostasis.pt_BR
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceLivestock Sciencept_BR
dc.subjectCaprinept_BR
dc.subjectFetal programmingpt_BR
dc.subjectRNA-seqpt_BR
dc.subjectMuscle metabolismpt_BR
dc.subjectUndernutritionpt_BR
dc.subjectCaprinospt_BR
dc.subjectProgramação fetalpt_BR
dc.subjectMetabolismo muscularpt_BR
dc.subjectDesnutrição animalpt_BR
dc.subjectMúsculo esqueléticopt_BR
dc.titleTranscriptome changes in newborn goats’ skeletal muscle as a result of maternal feed restriction at different stages of gestationpt_BR
dc.typeArtigopt_BR
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