Use este identificador para citar ou linkar para este item:
http://repositorio.ufla.br/jspui/handle/1/48859
Título: | Regulation of protein synthesis: an approach to treat Autistic Spectrum Disorder (ASD) |
Palavras-chave: | Neurodevelopment Translation mTOR eIF4E-eIF4G mGluR GRK5 Mammalian target of rapamycin (mTOR) |
Data do documento: | 19-Abr-2021 |
Editor: | Bentham Science Publishers |
Citação: | TEIXEIRA, J. P.; RAMALHO, T. C. Regulation of protein synthesis: an approach to treat Autistic Spectrum Disorder (ASD). Current Medicinal Chemistry, [S.l.], v. 28, n. 34, p. 7141-7156, Apr. 2021. DOI: 10.2174/0929867328666210419125634. |
Resumo: | Autism Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD impacts a large number of people in the world. Surprisingly, in spite of its great importance, just modest progress has been achieved towards comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs their development and plasticity, leading to characteristics of individuals with ASD. The present work investigates the mTOR pathway and the proteins related to its regulation and neurological functioning. The path of protein synthesis and translation is promising to treat various disorders and its elucidation may, for example, result in drugs that facilitate the diagnosis and broaden the range of treatments, improving the quality of life of ASD patients. |
URI: | https://www.eurekaselect.com/article/115384 http://repositorio.ufla.br/jspui/handle/1/48859 |
Aparece nas coleções: | DQI - Artigos publicados em periódicos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.