Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/48859
Título: Regulation of protein synthesis: an approach to treat Autistic Spectrum Disorder (ASD)
Palavras-chave: Neurodevelopment
Translation
mTOR
eIF4E-eIF4G
mGluR
GRK5
Mammalian target of rapamycin (mTOR)
Data do documento: 19-Abr-2021
Editor: Bentham Science Publishers
Citação: TEIXEIRA, J. P.; RAMALHO, T. C. Regulation of protein synthesis: an approach to treat Autistic Spectrum Disorder (ASD). Current Medicinal Chemistry, [S.l.], v. 28, n. 34, p. 7141-7156, Apr. 2021. DOI: 10.2174/0929867328666210419125634.
Resumo: Autism Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD impacts a large number of people in the world. Surprisingly, in spite of its great importance, just modest progress has been achieved towards comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs their development and plasticity, leading to characteristics of individuals with ASD. The present work investigates the mTOR pathway and the proteins related to its regulation and neurological functioning. The path of protein synthesis and translation is promising to treat various disorders and its elucidation may, for example, result in drugs that facilitate the diagnosis and broaden the range of treatments, improving the quality of life of ASD patients.
URI: https://www.eurekaselect.com/article/115384
http://repositorio.ufla.br/jspui/handle/1/48859
Aparece nas coleções:DQI - Artigos publicados em periódicos

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