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dc.creatorMoura, Rodrigo F. de-
dc.creatorNascimento, Lucas F.-
dc.creatorIgnacio-Souza, Leticia M.-
dc.creatorMorari, Joseane-
dc.creatorRazolli, Daniela S.-
dc.creatorSolon, Carina-
dc.creatorSouza, Gabriela F. P. de-
dc.creatorFestuccia, William T.-
dc.creatorVelloso, Licio A.-
dc.date.accessioned2021-01-04T17:42:57Z-
dc.date.available2021-01-04T17:42:57Z-
dc.date.issued2016-
dc.identifier.citationMOURA, R. F. de et al. Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure. International Journal of Obesity, London, v. 40, p. 471-478, 2016.pt_BR
dc.identifier.urihttps://www.nature.com/articles/ijo2015188pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/45962-
dc.description.abstractBackground/Objectives: Stearoyl-CoA desaturase-2 (SCD2) is the main δ9 desaturase expressed in the central nervous system. Because of its potential involvement in controlling whole-body adiposity, we evaluated the expression and function of SCD2 in the hypothalami of mice. Subjects/Methods: Male mice of different strains were used in real-time PCR, immunoblot and metabolic experiments. In addition, antisense oligonucleotides and lentiviral vectors were used to reduce and increase the expression of SCD2 in the hypothalamus. Results: The level of SCD2 in the hypothalamus is similar to other regions of the central nervous system and is ~10-fold higher than in any other region of the body. In the arcuate nucleus, SCD2 is expressed in proopiomelanocortin and neuropeptide-Y neurons. Upon high fat feeding, the level of hypothalamic SCD2 increases. Inhibition of hypothalamic SCD2 as accomplished by two distinct approaches, an antisense oligonucleotide or a short-hairpin RNA delivered by a lentivirus, resulted in reduced body mass gain mostly due to increased energy expenditure and increased spontaneous activity. Increasing hypothalamic SCD2 by a lentivirus approach resulted in no change in body mass and food intake. Conclusions: Thus, SCD2 is highly expressed in the hypothalami of rodents and its knockdown reduces body mass due to increased whole-body energy expenditure.pt_BR
dc.languageen_USpt_BR
dc.publisherSpringer Naturept_BR
dc.rightsrestrictAccesspt_BR
dc.sourceInternational Journal of Obesitypt_BR
dc.subjectHypothalamuspt_BR
dc.subjectMolecular neurosciencept_BR
dc.subjectObesitypt_BR
dc.subjectPhysiologypt_BR
dc.subjectHipotálamopt_BR
dc.subjectNeurociência molecularpt_BR
dc.subjectObesidadept_BR
dc.subjectFisiologiapt_BR
dc.titleHypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditurept_BR
dc.typeArtigopt_BR
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