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Título : | Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke |
Autor: | Lin, Chen Arevalo, Yurany A. Nanavati, Hely D. Lin, Diana M. |
Palavras-chave: | Stroke COVID-19 Coronavirus immune response Neutrophil-to-lymphocyte ratio Racial disparities |
Publicador: | Elsevier |
Data da publicação: | Out-2020 |
Referência: | LIN, C. et al. Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke. Brain, Behavior, & Immunity - Health, [S.l.], v. 8, Oct. 2020. |
Abstract: | Objective To describe the difference in clinical presentation, including race, of ischemic stroke between patients with and without novel coronavirus disease 2019 (COVID-19), and the association of inflammatory response with stroke severity. Methods This is a retrospective, observational, cross-sectional study of patients (n = 60) admitted with ischemic stroke between late March and early May 2020. All patients were tested for COVID-19 during admission. Demographic, clinical, and laboratory data was collected through electronic medical record review. Descriptive statistics was performed to observe the differences between stroke patients with and without COVID-19 Results 60 hospitalized patients with acute ischemic stroke were included in the analysis. Nine were positive for COVID-19. African-Americans comprised of 55.6% of those that had COVID-19 and stroke and 37.7% of those with only stroke. Stroke patients with COVID-19 had a significantly higher NIHSS [18.4 (8.8)] and neutrophil-to-lymphocyte ratio (NLR) [7.3 (4.2) vs 3.8 (2.8); P = 0.0137] than those without. Those with COVID-19 also had a significantly higher mortality rate (44.4% vs. 7.6%; p < 0.001). Conclusion We observed a cohort of patients, including a large proportion of African-Americans, who developed ischemic stroke with or without COVID-19. An exaggerated inflammatory response, as indicated by NLR, likely plays a role in stroke severity among COVID-19 patients that concurrently develop ischemic stroke. |
URI: | https://www.sciencedirect.com/science/article/pii/S2666354620301022 http://repositorio.ufla.br/jspui/handle/1/45420 |
Idioma: | en_US |
Aparece nas coleções: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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