Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/43058
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dc.creatorYazdanpanah, Fereshteh-
dc.creatorHamblin, Michael R.-
dc.creatorRezaei, Nima-
dc.date.accessioned2020-09-14T19:40:06Z-
dc.date.available2020-09-14T19:40:06Z-
dc.date.issued2020-09-
dc.identifier.citationYAZDANPANAH, F.; HAMBLIN, M. R.; REZAEI, N. The immune system and COVID-19: friend or foe? Life Sciences, [S.l.], v. 256, Sept. 2020.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0024320520306500pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/43058-
dc.description.abstractAim Coronavirus disease 2019 (COVID-19) is a novel highly contagious infection caused by SARS-CoV-2, which has been became a global public health challenge. The pathogenesis of this virus is not yet clearly understood, but there is evidence of a hyper-inflammatory immune response in critically ill patients, which leads to acute respiratory distress syndrome (ARDS) and multi-organ failure. Material and methods A literature review was performed to identify relevant articles on COVID-19 published up to April 30, 2020. The search resulted in 361 total articles. After reviewing the titles and abstracts for inclusion, some irrelevant papers were excluded. Additional relevant articles were identified from a review of citations referenced. Key findings SARS-CoV-2, directly and indirectly, affects the immune system and avoids being eliminated in early stages. On the other hand, the secretion of inflammatory cytokines creates critical conditions that lead to multi-organ failure. Significance The immune system which is affected by the virus tries to respond via a cytokine storm and hyperinflammation, which itself leads to further multi-organ damage and even death.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceLife Sciencespt_BR
dc.subjectCOVID-19pt_BR
dc.subjectImmune systempt_BR
dc.subjectAcute Respiratory Distress Syndrome (ARDS)pt_BR
dc.subjectHyperinflammationpt_BR
dc.subjectCytokine stormpt_BR
dc.titleThe immune system and COVID-19: friend or foe?pt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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