Use este identificador para citar ou linkar para este item:
http://repositorio.ufla.br/jspui/handle/1/41826| Título: | The MIA-QSAR method for the prediction of bioactivities of possible acetylcholinesterase inhibitors |
| Palavras-chave: | Acetylcholinesterase Carbamates MIA‐QSAR method Multivariate image analysis applied to quantitative structure-activity relationship (MIA-QSAR) |
| Data do documento: | 6-Jun-2012 |
| Editor: | Wiley |
| Citação: | BITENCOURT, M.; FREITAS, M. P.; RITTNER, R. The MIA-QSAR method for the prediction of bioactivities of possible acetylcholinesterase inhibitors. Archiv der Pharmazie: Chemistry in Life Sciences, [S.l.], v. 345, n. 9, p. 723-728, Sept. 2012. DOI: 10.1002/ardp.201200079. |
| Resumo: | This paper describes the use of the multivariate image analysis‐quantitative structure–activity relationship (MIA‐QSAR) methodology, which is a method capable of relating chemical structures with their biological activities. This in silico method has been shown to be extremely reliable and provides excellent results, even compared to those obtained by costly and time‐consuming methods. Here, a class of acetylcholinesterase inhibitors was studied and three new compounds exhibiting high estimated pIC50 values were found. They may be promising inhibitors for use in the treatment of Alzheimer's disease. |
| URI: | https://onlinelibrary.wiley.com/doi/10.1002/ardp.201200079 http://repositorio.ufla.br/jspui/handle/1/41826 |
| Aparece nas coleções: | DQI - Artigos publicados em periódicos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.