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Título: | Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
Palavras-chave: | 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside Periodontitis Oral Health Mouth Diseases Functional Food Periodontite Saúde Oral Doenças da Boca Alimento funcional Polifenóis |
Data do documento: | Mai-2019 |
Editor: | MDPI Journals |
Citação: | ANDRADE, E. F. et al. Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies. Nutrients, Basel, v. 11, n. 5, May 2019. DOI: 10.3390/nu11050953. |
Resumo: | Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression. |
URI: | http://repositorio.ufla.br/jspui/handle/1/40690 |
Aparece nas coleções: | DEG - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_n Resveratrol Treatment Control the Progression of Induced Periodontal Disease A Systematic Review and Meta-Analysis of Preclinical Studies.pdf | 833,1 kB | Adobe PDF | Visualizar/Abrir |
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