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dc.creatorGomes, Ricardo José-
dc.creatorLeme, José Alexandre Curiacos de Almeida-
dc.creatorMoura, Leandro Pereira de-
dc.creatorAraújo, Michel Barbosa de-
dc.creatorRogatto, Gustavo Puggina-
dc.creatorMoura, Rodrigo Ferreira de-
dc.creatorLuciano, Eliete-
dc.creatorMello, Maria Alice Rostom de-
dc.date.accessioned2019-12-06T16:46:45Z-
dc.date.available2019-12-06T16:46:45Z-
dc.date.issued2009-06-
dc.identifier.citationGOMES, R. J. et al. Growth factors and glucose homeostasis in diabetic rats: effects of exercise training. Cell Biochemistry and Function, [S.l.], v. 27, n. 4, p. 199-204, June 2009.pt_BR
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbf.1556pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/38066-
dc.description.abstractTo investigate the alterations of glucose homeostasis and variables of the insulin‐like growth factor‐1 (IGF‐1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg−1 b.w.). Training program consisted of swimming 5 days week−1, 1 h day−1, during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF‐1, and IGF binding protein‐3 (IGFBP‐3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF‐1 content. Diabetes decreased serum GH, IGF‐1, IGFBP‐3, liver glycogen, and cerebellum IGF‐1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF‐1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF‐1 concentrations.pt_BR
dc.languageen_USpt_BR
dc.publisherWiley Online Librarypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceCell Biochemistry and Functionpt_BR
dc.subjectDiabetespt_BR
dc.subjectGlucose homeostasispt_BR
dc.subjectInsulin-like growth factor-Ipt_BR
dc.titleGrowth factors and glucose homeostasis in diabetic rats: effects of exercise trainingpt_BR
dc.typeArtigopt_BR
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DME - Artigos publicados em periódicos

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