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dc.creatorSchiessel, Dalton Luiz-
dc.creatorYamazaki, Ricardo K.-
dc.creatorKryczyk, Marcelo-
dc.creatorCoelho, Isabela-
dc.creatorYamaguchi, Adriana A.-
dc.creatorPequito, Daniele C. T.-
dc.creatorBrito, Gleisson A. P.-
dc.creatorBorghetti, Gina-
dc.creatorFernandes, Luiz C.-
dc.date.accessioned2019-11-14T12:25:04Z-
dc.date.available2019-11-14T12:25:04Z-
dc.date.issued2015-
dc.identifier.citationSCHIESSEL, D. L. et al. α-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing rats. Nutrition and Cancer, [S.l.], v. 67, n. 5, 2015.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/37625-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/01635581.2015.1043021-
dc.description.abstractFish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specifically α-linolenic fatty acid (ALA), has controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), fed regular chow and supplemented with FO or Oro Inca oil (OI), and Walker 256 tumor-bearing rats fed regular chow (W), fed regular chow and supplemented with FO (WFO) or OI (WOI). Rats were supplemented (1g/kg body weight/day) during 4 wk and then the groups tumor-bearing were inoculated with Walker 256 tumor cells suspension and 14 days later the animals were killed. WFO increased EPA fivefold and DHA 1.5-fold in the tumor tissue compared to W (P < 0.05). OI supplementation increased of threefold of ALA when compared to W (P < 0.05). Tumor mass in WFO and OI was of 2.3-fold lower, as well as tumor cell proliferation of 3.0-fold tumor tissue lipoperoxidation increased of 76.6% and cox-2 expression was 20% lower. Cachexia parameters were attenuate, blood glucose (25% higher), Triacylglycerolemia (50% lower), and plasma TNF-α (65% lower; P < 0.05) and IL-6 (62.5% lower). OI, rich in ALA, caused the same effect on cancer as those seen in FO.pt_BR
dc.languageen_USpt_BR
dc.publisherTaylor & Francis Onlinept_BR
dc.rightsrestrictAccesspt_BR
dc.sourceNutrition and Cancerpt_BR
dc.titleα-Linolenic fatty acid supplementation decreases tumor growth and cachexia parameters in walker 256 tumor-bearing ratspt_BR
dc.typeArtigopt_BR
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