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dc.creatorMoreira, T. G.-
dc.creatorGomes-Santos, A. C.-
dc.creatorHorta, L. S.-
dc.creatorMiranda, M. C. G.-
dc.creatorSantiago, A. F.-
dc.creatorLauar, J. G.-
dc.creatorReis, D. S.-
dc.creatorBarbosa, A-
dc.creatorLemos, L.-
dc.creatorGuimarães, M-
dc.creatorAguilar, E. C.-
dc.creatorPap, A-
dc.creatorAmaral, J. F.-
dc.creatorAlvarez-Leite, J. I.-
dc.creatorCara, D. C.-
dc.creatorRezende, R. M.-
dc.creatorNagy, L-
dc.creatorFaria, A. M. C.-
dc.creatorMaioli, T. U.-
dc.date.accessioned2019-03-13T12:46:18Z-
dc.date.available2019-03-13T12:46:18Z-
dc.date.issued2018-07-
dc.identifier.citationMOREIRA, T. G. et al. Consumption of conjugated linoleic acid (CLA)-supplemented diet during colitis development ameliorates gut inflammation without causing steatosis in mice. The Journal of Nutritional Biochemistry, [S.l.], v. 57, p. 238-245, July 2018.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0955286317310276pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/33183-
dc.description.abstractDietary supplementation with conjugated linoleic acid (CLA) has been proposed for weight management and to prevent gut inflammation. However, some animal studies suggest that supplementation with CLA leads to the development of nonalcoholic fatty liver disease. The aims of this study were to test the efficiency of CLA in preventing dextran sulfate sodium (DSS)-induced colitis, to analyze the effects of CLA in the liver function, and to access putative liver alterations upon CLA supplementation during colitis. So, C57BL/6 mice were supplemented for 3 weeks with either control diet (AIN-G) or 1% CLA-supplemented diet. CLA content in the diet and in the liver of mice fed CLA containing diet were accessed by gas chromatography. On the first day of the third week of dietary treatment, mice received ad libitum a 1.5%–2.5% DSS solution for 7 days. Disease activity index score was evaluated; colon and liver samples were stained by hematoxylin and eosin for histopathology analysis and lamina propria cells were extracted to access the profile of innate cell infiltrate. Metabolic alterations before and after colitis induction were accessed by an open calorimetric circuit. Serum glucose, cholesterol, triglycerides and alanine aminotransaminase were measured; the content of fat in liver and feces was also accessed. CLA prevented weight loss, histopathologic and macroscopic signs of colitis, and inflammatory infiltration. Mice fed CLA-supplemented without colitis induction diet developed steatosis, which was prevented in mice with colitis probably due to the higher lipid consumption as energy during gut inflammation. This result suggests that CLA is safe for use during gut inflammation but not at steady-state conditions.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceThe Journal of Nutritional Biochemistrypt_BR
dc.subjectConjugated linoleic acid (CLA)pt_BR
dc.subjectSteatosispt_BR
dc.subjectColitispt_BR
dc.subjectDextran sulfate sodium (DSSpt_BR
dc.subjectInflammationpt_BR
dc.subjectMetabolismpt_BR
dc.titleConsumption of conjugated linoleic acid (CLA)-supplemented diet during colitis development ameliorates gut inflammation without causing steatosis in micept_BR
dc.typeArtigopt_BR
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