Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/32518
Título: Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae)
Palavras-chave: Psychotria stenocalyx
Antiinflammatory
Monoterpene indole alkaloids
Antiinflamatório
Alcalóides indólicos monoterpénicos
Data do documento: Abr-2017
Editor: ScopeMed
Citação: QUEIROZ, G. S. et al. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). Journal of Applied Pharmaceutical Science, [S. l.], v. 7, n. 4, p. 168-173, Apr. 2017.
Resumo: In this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6&′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species.
URI: http://repositorio.ufla.br/jspui/handle/1/32518
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