Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/29786
Título: Methyl and p-Bromobenzyl esters of hydrogenated kaurenoic acid for controlling anthracnose in common bean plants
Palavras-chave: Colletotrichum lindemuthianum
Ketosteroid isomerase
Fungicide
Fungicida
Data do documento: 2017
Editor: American Chemical Society
Citação: MOTA, S. F. et al. Methyl and p-Bromobenzyl esters of hydrogenated kaurenoic acid for controlling anthracnose in common bean plants. Journal of Agricultural and Food Chemistry, [S.l.], v. 65, n. 8, p. 1489-1495, 2017.
Resumo: Kaurenoic acid derivatives were prepared and submitted to in vitro assays with the fungus Colletotrichum lindemuthianum, which causes anthracnose disease in the common bean. The most active substances were found to be methyl and p-bromobenzylesters, 7 and 9, respectively, of the hydrogenated kaurenoic acid, which presented a minimum inhibitory concentration (MIC) of 0.097 and 0.131 mM, respectively, while the commercial fungicide methyl thiophanate (MT) presented a MIC of 0.143 mM. Substances 7 (1.401 mM) and 9 (1.886 mM) reduced the severity of anthracnose in common bean to values statistically comparable to MT (2.044 mM). According to an in silico study, both compounds 7 and 9 are inhibitors of the ketosteroid isomerase (KSI) enzyme produced by other organisms, the amino acid sequence of which could be detected in fungal genomes. These substances appeared to act against C. lindemuthianum by inhibiting its KSI. Therefore, substances 7 and 9 are promising for the development of new fungicides.
URI: https://pubs.acs.org/doi/10.1021/acs.jafc.6b05159
http://repositorio.ufla.br/jspui/handle/1/29786
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