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dc.creatorMesquita, Vanessa A.-
dc.creatorMachado, Manuela D.-
dc.creatorSilva, Cristina F.-
dc.creatorSoares, Eduardo V.-
dc.date.accessioned2018-07-13T11:16:25Z-
dc.date.available2018-07-13T11:16:25Z-
dc.date.issued2016-11-
dc.identifier.citationMESQUITA, V. A. et al. Influence of the metabolic state on the tolerance of Pichia kudriavzevii to heavy metals. Journal of Basic Microbiology, Weinheim, v. 56, n. 11, p. 1244-1251, Nov. 2016.pt_BR
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/jobm.201600232pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/29625-
dc.description.abstractThis work aims to examine the influence of the metabolic state of the yeast Pichia kudriavzevii on the susceptibility to a metals mixture (5 mg L−1 Cd, 10 mg L−1 Pb, and 5 mg L−1 Zn). Cells exposed to the metals mixture in the presence of 25 mmol L−1 glucose displayed a higher loss of membrane integrity and proliferation capacity, compared to cells incubated in the absence of glucose. The analysis of the effect of individual metals revealed that glucose increased the toxic effect of Cd marginally, and of Pb significantly. The increased susceptibility to heavy metals due to glucose was attenuated in the simultaneous presence of a mitochondrial respiration inhibitor such as sodium azide (NaN3). ATP‐depleted yeast cells, resulting from treatment with the non‐metabolizable glucose analogue 2‐deoxy‐d‐glucose, showed an increased susceptibility to heavy metals mixture. Pre‐incubation of yeast cells with 1 or 1.5 mmol L−1 Ca2+ reduced significantly (P < 0.05) the loss of membrane integrity induced by the metals mixture. These findings contribute to the understanding of metals mechanisms of toxicity in the non‐conventional yeast P. kudriavzevii.pt_BR
dc.languageen_USpt_BR
dc.publisherWileypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Basic Microbiologypt_BR
dc.subject2‐deoxy‐d‐glucose (2‐DOG)pt_BR
dc.subjectHeavy metals toxicitypt_BR
dc.subjectMembrane integritypt_BR
dc.subjectSodium azidept_BR
dc.subjectYeast viabilitypt_BR
dc.subject2 desoxi-d-glicose (2-DOG)pt_BR
dc.subjectToxicidade de metais pesadospt_BR
dc.subjectIntegridade da membranapt_BR
dc.subjectAzida de sódiopt_BR
dc.subjectViabilidade de levedurapt_BR
dc.titleInfluence of the metabolic state on the tolerance of Pichia kudriavzevii to heavy metalspt_BR
dc.typeArtigopt_BR
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