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dc.creatorBezerra, Otávio C.-
dc.creatorFrança, Cristiane Miranda-
dc.creatorRocha, Juraci Aparecida-
dc.creatorNeves, Gizele A.-
dc.creatorSouza, Pamella Ramona M.-
dc.creatorGomes, Mariana Teixeira-
dc.creatorMalftano, Christiane-
dc.creatorLoleiro, Tatiane C. Alba-
dc.creatorDourado, Paulo Magno-
dc.creatorLlesuy, Susana-
dc.creatorAngelis, Katia de-
dc.creatorIrigoyen, Maria Claudia C.-
dc.creatorUlloa, Luis-
dc.creatorConsolim-Colombo, Fernanda M.-
dc.date.accessioned2018-06-21T18:45:29Z-
dc.date.available2018-06-21T18:45:29Z-
dc.date.issued2017-10-20-
dc.identifier.citationBEZERRA, O. C. et al. Cholinergic stimulation improves oxidative stress and inflammation in experimental myocardial infarction. Scientific Reports, [S. l.], v. 7, p. 1-12, 20 oct. 2017. doi: https://doi.org/10.1038/s41598-017-14021-8.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/29479-
dc.description.abstractWe previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the anti-inflammatory effects of PY during the proliferative phase of cardiac repair by analyzing the infiltration of macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation of the left coronary artery and were randomly allocated to remain untreated (untreated infarcted group, I) or to receive PY (30 mg·kg(−1)·day(−1)) in the supplied water (infarcted treated group, I + PY). Blood pressure and heart rate variability were registered at day 5 post-MI. The animals were euthanized 7 days after thoracotomy, when the hearts were removed and processed for immunohistochemistry (CD68, CD206, FOXP3), cytokines (IL-1β, IL-6, IL-10, TNF-α) and oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation). PY treatment increased parasympathetic modulation, M2 macrophages and the anti-oxidant enzyme activity but reduced protein oxidation (carbonyls) and the concentration of IL-1β, IL-6, TNF-α and IL-10. Cholinergic stimulation induces parasympathetic neuro-immune modulation and anti-inflammatory cell enrollment as well as prevents oxidative stress and cytokine production after MI.pt_BR
dc.languageen_USpt_BR
dc.publisherNaturept_BR
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceScientific Reportspt_BR
dc.subjectMyocardial infarctionpt_BR
dc.subjectCholinergic stimulationpt_BR
dc.subjectOxidative stresspt_BR
dc.subjectInfarto do miocárdiopt_BR
dc.subjectEstimulação colinérgicapt_BR
dc.subjectEstresse oxidativopt_BR
dc.titleCholinergic stimulation improves oxidative stress and inflammation in experimental myocardial infarctionpt_BR
dc.typeArtigopt_BR
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