Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/28481
Título: Toxoplasmose: perspectivas no estudo de novos alvos terapêuticos
Palavras-chave: Toxoplasmose - Tratamento
Química computacional
Alvos terapêuticos
Toxoplasmosis - Treatment
Computational chemistry
Therapeutic targets
Data do documento: Jul-2012
Editor: Sociedade Brasileira de Química
Citação: MANCINI, D. T. et al. Toxoplasmose: perspectivas no estudo de novos alvos terapêuticos. Revista Virtual de Química, Niterói, v. 4, n. 4, p. 434-455, jul./ago. 2012.
Resumo: Toxoplasma gondii is an intracellular parasite responsible for causing the disease known as toxoplasmosis. This protozoan is easily found in nature and can cause infections in birds and mammals. Currently the toxoplasmosis treatment presents some limitations since the drugs used show low efficiency and can cause serious side-effects. Based on these therapeutic limitations arises the need for design and discovering more potent and selective new drugs against toxoplasmosis. In this context, the computational medicinal chemistry has been used as an important tool in the discovery of new therapeutic targets in the causative agents of several diseases, including toxoplasmosis. This work aims to quickly discuss some new molecular targets such as adenosine kinase, dihydrofolatereductase and thymidylate synthase enzymes, which have been exploited by computational techniques (docking and comparative modeling) in order to direct the planning of new drugs against toxoplasmosis.
URI: http://repositorio.ufla.br/jspui/handle/1/28481
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