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Campo DC | Valor | Idioma |
---|---|---|
dc.creator | Ramalho, Teodorico C. | - |
dc.creator | Rocha, Marcus V. J. | - |
dc.creator | Cunha, Elaine F. F. da | - |
dc.date.accessioned | 2017-10-11T18:47:29Z | - |
dc.date.available | 2017-10-11T18:47:29Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | RAMALHO, T. C.; ROCHA, M. V. J.; CUNHA, E. F. F. The search for new COX-2 inhibitors: a review of 2002 - 2008 patents. Expert Opinion on Therapeutic Patents, [S. l.], v. 19, n. 9, p. 1193-1228, 2009. | pt_BR |
dc.identifier.uri | http://www.tandfonline.com/doi/abs/10.1517/13543770903059125?journalCode=ietp20 | pt_BR |
dc.identifier.uri | repositorio.ufla.br/jspui/handle/1/15528 | - |
dc.description.abstract | Background: Two COX isoenzymes are known, COX-1 and COX-2, for which the main inhibitors are the NSAIDs. The common anti-inflammatory drugs (such as aspirin, ibuprofen and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes. The COX-2 inhibitors represent a new class of drugs that do not affect COX-1 but selectively block COX-2. This selective action provides the benefits of reducing inflammation without irritating the stomach and cardiovascular effects. Objective: This review focuses on patents published in the field during 2002 – 2008, paying particular attention to promising COX-2 inhibitors. Conclusion: Structural analogues of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole and thione derivatives emerge as promising leads for the treatment of inflammation, pain and other diseases. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | Taylor & Francis | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Expert Opinion on Therapeutic Patents | pt_BR |
dc.subject | Anti-inflammatory drugs | pt_BR |
dc.subject | COX-2 | pt_BR |
dc.subject | NSAIDs | pt_BR |
dc.subject | Anti-inflamatórios | pt_BR |
dc.title | The search for new COX-2 inhibitors: a review of 2002 - 2008 patents | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | DQI - Artigos publicados em periódicos |
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