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dc.creatorDe la Cruz, M. N.-
dc.creatorM. Júnior, H.-
dc.creatorOliveira, D. F.-
dc.creatorCosta-Lotufo, L. V.-
dc.creatorFerreira, A. G.-
dc.creatorAlviano, D. S.-
dc.creatorRezende, C. M.-
dc.date.accessioned2017-10-11T18:08:29Z-
dc.date.available2017-10-11T18:08:29Z-
dc.date.issued2013-
dc.identifier.citationDE LA CRUZ, H. N. et al. Chemical composition and biological activities of soldiers of the Brazilian termite species, Nasutitermes macrocephalus (Isoptera: Natutitermitinae). Natural Product Communications, v. 8, n. 1, p. 69-74, 2013.pt_BR
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/23472463pt_BR
dc.identifier.urirepositorio.ufla.br/jspui/handle/1/15507-
dc.description.abstractThe defensive secretion of the frontal gland from termite soldiers is a mixture of monoterpenes, sesquiterpenes and diterpenes, the latter being the most representative. Analyses of the dichloromethane extract from soldiers of the Brazilian termite, Nasutitermes macrocephalus (Silvestri, 1903) (Isoptera, Nasutitermitinae), described for the first time, allowed to identify the presence of two monoterpenes (alpha-pinene and limonene) and two sesquiterpenes (beta-trans-caryophyllene and gamma-selinene) [corrected] by GC-EIMS, and the isolation of one rippertane and six trinervitane diterpenes by RP-HPLC. The chemical structures of the purified compounds were elucidated by interpretation of their spectroscopic data (1D and 2D NMR, EIMS, HRESIMS, and specific optical rotation) and the complete unequivocal assignment of the 3a-hydroxy-trinervita-1(15),8(19)-dien-2-one (6) was included in this paper, to complement the lack of information in the literature. Antibacterial, antifungal and cytotoxicity against cancer cell lines activities were evaluated. In particular, the compounds 2alpha,3beta-dihydroxytrinervita-l(15),8(19)-diene (2) and 3alpha-hydroxy-15-rippertene (7) exhibited the better activities against the clinically isolated Gram-positive bacterium methicillin-resistant Staphylococcus aureus BMB 9393, both with a MIC value of 31.2 microg mL(-1). This is the first description of a rippertane diterpene (7) as an antibacterial agent.pt_BR
dc.languageen_USpt_BR
dc.publisherPubMedpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceNatural Product Communicationspt_BR
dc.subjectBrazilian termite - Chemical compositionpt_BR
dc.subjectBrazilian termite - Biological activitiespt_BR
dc.subjectAntibacterial agentpt_BR
dc.subjectMonoterpenespt_BR
dc.subjectSesquiterpenespt_BR
dc.subjectCupim - Composição químicapt_BR
dc.subjectCupim - Atividade biológicapt_BR
dc.subjectAgente antibacterianopt_BR
dc.subjectMonoterpenospt_BR
dc.subjectSesquiterpenospt_BR
dc.titleChemical composition and biological activities of soldiers of the Brazilian termite species, Nasutitermes macrocephalus (Isoptera: Natutitermitinae)pt_BR
dc.typeArtigopt_BR
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