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DC Field | Value | Language |
---|---|---|
dc.creator | Sousa, Frederico B. de | - |
dc.creator | Lima, Ana C. | - |
dc.creator | Denadai, Ângelo M. L. | - |
dc.creator | Anconi, Cleber P. A. | - |
dc.creator | Almeida, Wagner B. de | - |
dc.creator | Novato, Willian T. G. | - |
dc.creator | Santos, Hélio F. dos | - |
dc.creator | Drum, Chester L. | - |
dc.creator | Langer, Robert | - |
dc.creator | Sinisterra, Rubén D. | - |
dc.date.accessioned | 2017-08-14T12:11:50Z | - |
dc.date.available | 2017-08-14T12:11:50Z | - |
dc.date.issued | 2012-02-14 | - |
dc.identifier.citation | SOUSA, F. B. de et al. Superstructure based on β-CD self-assembly induced by a small guest molecule. Physical Chemistry Chemical Physics, Cambridge, v. 14, n. 6, p. 1934-1944, 14 Feb. 2012. | pt_BR |
dc.identifier.uri | http://pubs.rsc.org/en/content/articlelanding/2012/cp/c2cp22768a#!divAbstract | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/15155 | - |
dc.description.abstract | The size, shape and surface chemistry of nanoparticles play an important role in cellular interaction. Thus, the main objective of the present study was the determination of the β-cyclodextrin (β-CD) self-assembly thermodynamic parameters and its structure, aiming to use these assemblies as a possible controlled drug release system. Light scattering measurements led us to obtain the β-CD’s critical aggregation concentration (cac) values, and consequently the thermodynamic parameters of the β-CD spontaneous self-assembly in aqueous solution: ΔaggGo = − 16.31 kJ mol−1, ΔaggHo = − 26.48 kJ mol−1 and TΔaggSo = − 10.53 kJ mol−1 at 298.15 K. Size distribution of the self-assembled nanoparticles below and above cac was 1.5 nm and 60–120 nm, respectively. The number of β-CD molecules per cluster and the second virial coefficient were identified through Debye’s plot and molecular dynamic simulations proposed the three-fold assembly for this system below cac. Ampicillin (AMP) was used as a drug model in order to investigate the key role of the guest molecule in the self-assembly process and the β-CD:AMP supramolecular system was studied in solution, aiming to determine the structure of the supramolecular aggregate. Results obtained in solution indicated that the β-CD’s cac was not affected by adding AMP. Moreover, different complex stoichiometries were identified by nuclear magnetic resonance and isothermal titration calorimetry experiments. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | National Institute of Health | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Physical Chemistry Chemical Physics | pt_BR |
dc.subject | Nanoparticles - Surface chemistry | pt_BR |
dc.subject | Nanopartículas - Química superficial | pt_BR |
dc.title | Superstructure based on β-CD self-assembly induced by a small guest molecule | pt_BR |
dc.type | Artigo | pt_BR |
Appears in Collections: | DQI - Artigos publicados em periódicos |
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