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Campo DC | Valor | Idioma |
---|---|---|
dc.creator | Moreira, Maria Eliza Castro | - |
dc.creator | Pereira, Rosemary Gualberto Fonseca Alvarenga | - |
dc.creator | Silva, Marcelo Jose Dias | - |
dc.creator | Dias, Danielle Ferreira | - |
dc.creator | Gontijo, Vanessa Silva | - |
dc.creator | Giusti-Paiva, Alexandre | - |
dc.creator | Veloso, Marcia Paranho | - |
dc.creator | Doriguetto, Antônio Carlos | - |
dc.creator | Nagem, Tanus Jorge | - |
dc.creator | Santos, Marcelo Henrique dos | - |
dc.date.accessioned | 2016-03-17T18:13:02Z | - |
dc.date.available | 2016-03-17T18:13:02Z | - |
dc.date.issued | 2014-06-12 | - |
dc.identifier.citation | MOREIRA, M. E. C. et al. Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae). Journal of Medicinal Food, New Rochelle, v. 17, n. 6, p. 686-693, June 2014. | pt_BR |
dc.identifier.uri | http://online.liebertpub.com/doi/abs/10.1089/jmf.2013.0122 | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/10924 | - |
dc.description.abstract | In the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20 mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90 min of treatment. At doses of 10 and 20 mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | Mary Ann Liebert | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Journal of Medicinal Food | pt_BR |
dc.subject | Analgesic effect | pt_BR |
dc.subject | Anti-inflammatory activity | pt_BR |
dc.subject | Edema | pt_BR |
dc.subject | Inflammation | pt_BR |
dc.subject | Oxygenated xanthone | pt_BR |
dc.title | Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae) | pt_BR |
dc.type | Artigo | pt_BR |
Aparece nas coleções: | DCA - Artigos publicados em periódicos |
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