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dc.creatorMoreira, Maria Eliza Castro-
dc.creatorPereira, Rosemary Gualberto Fonseca Alvarenga-
dc.creatorSilva, Marcelo Jose Dias-
dc.creatorDias, Danielle Ferreira-
dc.creatorGontijo, Vanessa Silva-
dc.creatorGiusti-Paiva, Alexandre-
dc.creatorVeloso, Marcia Paranho-
dc.creatorDoriguetto, Antônio Carlos-
dc.creatorNagem, Tanus Jorge-
dc.creatorSantos, Marcelo Henrique dos-
dc.date.accessioned2016-03-17T18:13:02Z-
dc.date.available2016-03-17T18:13:02Z-
dc.date.issued2014-06-12-
dc.identifier.citationMOREIRA, M. E. C. et al. Analgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae). Journal of Medicinal Food, New Rochelle, v. 17, n. 6, p. 686-693, June 2014.pt_BR
dc.identifier.urihttp://online.liebertpub.com/doi/abs/10.1089/jmf.2013.0122pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/10924-
dc.description.abstractIn the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20 mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90 min of treatment. At doses of 10 and 20 mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the mechanism of action of anti-inflammatory activity of the xanthone, a molecular docking was performed using the isoenzymes cyclooxygenase 1 and 2 and the results indicate that the molecule is capable of inhibiting both the enzymes. Therefore, it can be concluded that 2,8-dihydroxy-1,6-dimethoxyxanthone from H. paniculata demonstrates analgesic, anti-inflammatory, and antioxidant activities.pt_BR
dc.languageen_USpt_BR
dc.publisherMary Ann Liebertpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Medicinal Foodpt_BR
dc.subjectAnalgesic effectpt_BR
dc.subjectAnti-inflammatory activitypt_BR
dc.subjectEdemapt_BR
dc.subjectInflammationpt_BR
dc.subjectOxygenated xanthonept_BR
dc.titleAnalgesic and anti-Inflammatory activities of the 2,8-dihydroxy-1,6-dimethoxyxanthone from Haploclathra paniculata (mart) benth (guttiferae)pt_BR
dc.typeArtigopt_BR
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